Bacopa Monnieraplant Extract (bme) as Cognitive Enhancer in Alzheimer’s Disease (ad) Induced Albino Mice

Present study investigates the cognitive effects of BME on memory impairment in AD induced mice. Male Albino mice, Musmusculus of one month old weighing 20 ± 2 grams, were used as experimental model and were maintained according to ethical guidelines for animal protection and welfare. Mice were divided in to four groups as follows: Group I: Control mice; Group II: mice treated with BME; Group III (AD induced): mice treated with D-Gal & NaNO2; Group IV: AD induced mice simultaneously treated with BME. Changes in Morphometric and Behavioural aspects of four groups were analyzed by using Morris Water Maze technique. Results revealed that administration of Bacopamonniera to mice caused a phenomenal gain in body weight and enhanced the learning skills, memory and concentration whereas in AD induced mice very severe learning and memory deficits were observed. However, these deficiencies in AD induced mice could be ameliorated by simultaneous administration of BME and mice restored normal condition. From these observations, it was finally concluded that BME had potential compounds which can prevent the learning and memory deficits effectively and thus confer neuroprotection against Alzheimer’s disease.